Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia

Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major brea...

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Autores principales: Ma, Gina, Wang, Yi, Ahmed, Tahmeena, Zaslav, Ann-Leslie, Hogan, Laura, Avila, Cecilia, Wada, Masayuki, Salman, Huda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993359/
https://www.ncbi.nlm.nih.gov/pubmed/29892548
http://dx.doi.org/10.1016/j.lrr.2018.03.002
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author Ma, Gina
Wang, Yi
Ahmed, Tahmeena
Zaslav, Ann-Leslie
Hogan, Laura
Avila, Cecilia
Wada, Masayuki
Salman, Huda
author_facet Ma, Gina
Wang, Yi
Ahmed, Tahmeena
Zaslav, Ann-Leslie
Hogan, Laura
Avila, Cecilia
Wada, Masayuki
Salman, Huda
author_sort Ma, Gina
collection PubMed
description Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, little information exists on using CD19CAR for other CD19 positive neoplasms such as AML. Our findings indicate that CD19CAR therapy can potentially be used for those with mixed phenotype leukemia and a subset of AML cases.
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spelling pubmed-59933592018-06-11 Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia Ma, Gina Wang, Yi Ahmed, Tahmeena Zaslav, Ann-Leslie Hogan, Laura Avila, Cecilia Wada, Masayuki Salman, Huda Leuk Res Rep Article Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, little information exists on using CD19CAR for other CD19 positive neoplasms such as AML. Our findings indicate that CD19CAR therapy can potentially be used for those with mixed phenotype leukemia and a subset of AML cases. Elsevier 2018-03-27 /pmc/articles/PMC5993359/ /pubmed/29892548 http://dx.doi.org/10.1016/j.lrr.2018.03.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ma, Gina
Wang, Yi
Ahmed, Tahmeena
Zaslav, Ann-Leslie
Hogan, Laura
Avila, Cecilia
Wada, Masayuki
Salman, Huda
Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
title Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
title_full Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
title_fullStr Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
title_full_unstemmed Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
title_short Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
title_sort anti-cd19 chimeric antigen receptor targeting of cd19 + acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993359/
https://www.ncbi.nlm.nih.gov/pubmed/29892548
http://dx.doi.org/10.1016/j.lrr.2018.03.002
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