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Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer cells using the therapeutic nanocomplex scL-53....

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Detalles Bibliográficos
Autores principales: Moore, Ellen C., Sun, Lillian, Clavijo, Paul E., Friedman, Jay, Harford, Joe B., Saleh, Anthony D., Van Waes, Carter, Chang, Esther H., Allen, Clint T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993490/
https://www.ncbi.nlm.nih.gov/pubmed/29900037
http://dx.doi.org/10.1080/2162402X.2017.1404216