Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy

We investigated the effects of chloroquine (CQ) and amodiaquine (AQ) on AMPK phosphorylation in renal tubular cells in a diabetic environment in vivo and in vitro. We also examined whether CQ- or AQ-mediated AMPK activity restoration attenuated diabetic tubulopathy by normalizing mitochondrial fragm...

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Detalles Bibliográficos
Autores principales: Jeong, Hye Yun, Kang, Jun Mo, Jun, Hak Hoon, Kim, Dong-Jin, Park, Seon Hwa, Sung, Min Ji, Heo, Jin Hyung, Yang, Dong Ho, Lee, Sang Ho, Lee, So-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993726/
https://www.ncbi.nlm.nih.gov/pubmed/29884802
http://dx.doi.org/10.1038/s41598-018-26858-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993726/
https://www.ncbi.nlm.nih.gov/pubmed/29884802
http://dx.doi.org/10.1038/s41598-018-26858-8

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