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The Drosophila homologue of MEGF8 is essential for early development

Mutations of the gene MEGF8 cause Carpenter syndrome in humans, and the mouse orthologue has been functionally associated with Nodal and Bmp4 signalling. Here, we have investigated the phenotype associated with loss-of-function of CG7466, a gene that encodes the Drosophila homologue of MEGF8. We gen...

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Detalles Bibliográficos
Autores principales: Lloyd, Deborah L., Toegel, Markus, Fulga, Tudor A., Wilkie, Andrew O. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993795/
https://www.ncbi.nlm.nih.gov/pubmed/29884872
http://dx.doi.org/10.1038/s41598-018-27076-y