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Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
Most HIV-1 Tat is unconventionally secreted by infected cells following Tat interaction with phosphatidylinositol (4,5) bisphosphate (PI(4,5)P(2)) at the plasma membrane. Extracellular Tat is endocytosed by uninfected cells before escaping from endosomes to reach the cytosol and bind PI(4,5)P(2). It...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993824/ https://www.ncbi.nlm.nih.gov/pubmed/29884859 http://dx.doi.org/10.1038/s41467-018-04674-y |