Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

Most HIV-1 Tat is unconventionally secreted by infected cells following Tat interaction with phosphatidylinositol (4,5) bisphosphate (PI(4,5)P(2)) at the plasma membrane. Extracellular Tat is endocytosed by uninfected cells before escaping from endosomes to reach the cytosol and bind PI(4,5)P(2). It...

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Detalles Bibliográficos
Autores principales: Chopard, Christophe, Tong, Phuoc Bao Viet, Tóth, Petra, Schatz, Malvina, Yezid, Hocine, Debaisieux, Solène, Mettling, Clément, Gross, Antoine, Pugnière, Martine, Tu, Annie, Strub, Jean-Marc, Mesnard, Jean-Michel, Vitale, Nicolas, Beaumelle, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993824/
https://www.ncbi.nlm.nih.gov/pubmed/29884859
http://dx.doi.org/10.1038/s41467-018-04674-y

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