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MERIT reveals the impact of genomic context on sequencing error rate in ultra-deep applications
BACKGROUND: Rapid progress in high-throughput sequencing (HTS) and the development of novel library preparation methods have improved the sensitivity of detecting mutations in heterogeneous samples, specifically in high-depth (> 500×) clinical applications. However, HTS methods are bounded by the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994075/ https://www.ncbi.nlm.nih.gov/pubmed/29884116 http://dx.doi.org/10.1186/s12859-018-2223-1 |