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Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination

Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in the striatum, followed by the prefrontal...

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Detalles Bibliográficos
Autores principales: Tan, Laura Hui-Ru, Tan, Angela Jin-Rong, Ng, Yu-Ying, Chua, John Jia-En, Chew, Wee-Siong, Muralidharan, Sneha, Torta, Federico, Dutta, Bamaprasad, Sze, Siu Kwan, Herr, Deron R., Ong, Wei-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994222/
https://www.ncbi.nlm.nih.gov/pubmed/29043558
http://dx.doi.org/10.1007/s12035-017-0784-z