SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity

BACKGROUND: Small mothers against decapentaplegic (SMAD)4 and SMAD7 are key regulatory components in the immunosuppressive transforming growth factor- (TGF-) β signaling pathway, which is defective in inflammatory bowel disease (IBD). SMAD4 may play an important role in the pathogenesis of IBD as in...

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Detalles Bibliográficos
Autores principales: Klausen, Pia, Karstensen, John Gásdal, Coskun, Mehmet, Săftoiu, Adrian, Vilmann, Peter, Cowland, Jack Bernard, Riis, Lene Buhl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994270/
https://www.ncbi.nlm.nih.gov/pubmed/29977289
http://dx.doi.org/10.1155/2018/9307848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994270/
https://www.ncbi.nlm.nih.gov/pubmed/29977289
http://dx.doi.org/10.1155/2018/9307848

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