Gender Differences in Elderly With Subjective Cognitive Decline

Objective: Subjective cognitive decline (SCD), also known as significant memory concern (SMC), has been suggested as a manifestation of Alzheimer’s Disease (AD) preceding mild cognitive impairment (MCI). This study assessed the impact of gender on cognition, amyloid accumulation, the volumes of hipp...

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Autores principales: Wang, Lijun, Tian, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994539/
https://www.ncbi.nlm.nih.gov/pubmed/29915534
http://dx.doi.org/10.3389/fnagi.2018.00166
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author Wang, Lijun
Tian, Ting
author_facet Wang, Lijun
Tian, Ting
author_sort Wang, Lijun
collection PubMed
description Objective: Subjective cognitive decline (SCD), also known as significant memory concern (SMC), has been suggested as a manifestation of Alzheimer’s Disease (AD) preceding mild cognitive impairment (MCI). This study assessed the impact of gender on cognition, amyloid accumulation, the volumes of hippocampus, entorhinal cortex (EC), fusiform and medial temporal lobe (MTA) and cerebrospinal fluid (CSF) pathology biomarkers in patients reporting SMC. Methods: Twenty-nine males (mean age ± SD: 72.3 ± 5.7 years) and 40 females (mean age ± SD: 71.0 ± 5.1 years) with SMC from the AD Neuroimaging Initiative (ADNI) were included in the study. We explored the gender discrepancies in cognition, [(18)F] AV45 amyloid positivity, volumes of hippocampus, EC, fusiform and MTA and CSF biomarkers. Results: Compared with females, males showed significantly worse performance in Assessment Scale-cognitive subscale 13 (ADAS-13; P = 0.004) and lower amyloid deposition (P < 0.001). However, females showed greater advantage on the task of Rey Auditory Verbal Learning Test-5 (RAVLT-5) sum (P = 0.021), RAVLT-immediate recall (P = 0.010) and reduced volumes of the hippocampus, EC, fusiform and MTA (P = 0.001, P < 0.001, P < 0.001, P = 0.007) than males. No gender differences were found in CSF Aβ42, CSF Tau and CSF P-tau (P = 0.264, P = 0.454, P = 0.353). Conclusions: These findings highlight that gender discrepancies should be considered in the interpretation of cognitive measures when evaluating SMC.
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spelling pubmed-59945392018-06-18 Gender Differences in Elderly With Subjective Cognitive Decline Wang, Lijun Tian, Ting Front Aging Neurosci Neuroscience Objective: Subjective cognitive decline (SCD), also known as significant memory concern (SMC), has been suggested as a manifestation of Alzheimer’s Disease (AD) preceding mild cognitive impairment (MCI). This study assessed the impact of gender on cognition, amyloid accumulation, the volumes of hippocampus, entorhinal cortex (EC), fusiform and medial temporal lobe (MTA) and cerebrospinal fluid (CSF) pathology biomarkers in patients reporting SMC. Methods: Twenty-nine males (mean age ± SD: 72.3 ± 5.7 years) and 40 females (mean age ± SD: 71.0 ± 5.1 years) with SMC from the AD Neuroimaging Initiative (ADNI) were included in the study. We explored the gender discrepancies in cognition, [(18)F] AV45 amyloid positivity, volumes of hippocampus, EC, fusiform and MTA and CSF biomarkers. Results: Compared with females, males showed significantly worse performance in Assessment Scale-cognitive subscale 13 (ADAS-13; P = 0.004) and lower amyloid deposition (P < 0.001). However, females showed greater advantage on the task of Rey Auditory Verbal Learning Test-5 (RAVLT-5) sum (P = 0.021), RAVLT-immediate recall (P = 0.010) and reduced volumes of the hippocampus, EC, fusiform and MTA (P = 0.001, P < 0.001, P < 0.001, P = 0.007) than males. No gender differences were found in CSF Aβ42, CSF Tau and CSF P-tau (P = 0.264, P = 0.454, P = 0.353). Conclusions: These findings highlight that gender discrepancies should be considered in the interpretation of cognitive measures when evaluating SMC. Frontiers Media S.A. 2018-06-04 /pmc/articles/PMC5994539/ /pubmed/29915534 http://dx.doi.org/10.3389/fnagi.2018.00166 Text en Copyright © 2018 Wang and Tian for the Alzheimer’s Disease Neuroimaging Initiative. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Lijun
Tian, Ting
Gender Differences in Elderly With Subjective Cognitive Decline
title Gender Differences in Elderly With Subjective Cognitive Decline
title_full Gender Differences in Elderly With Subjective Cognitive Decline
title_fullStr Gender Differences in Elderly With Subjective Cognitive Decline
title_full_unstemmed Gender Differences in Elderly With Subjective Cognitive Decline
title_short Gender Differences in Elderly With Subjective Cognitive Decline
title_sort gender differences in elderly with subjective cognitive decline
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994539/
https://www.ncbi.nlm.nih.gov/pubmed/29915534
http://dx.doi.org/10.3389/fnagi.2018.00166
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