Crystal Structure of Entamoeba histolytica Cdc45 Suggests a Conformational Switch that May Regulate DNA Replication

Cdc45 plays a critical role at the core of the eukaryotic DNA replisome, serving as an essential scaffolding component of the replicative helicase holoenzyme Cdc45-MCM-GINS (CMG) complex. A 1.66-Å-resolution crystal structure of the full-length Cdc45 protein from Entamoeba histolytica shows a protei...

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Detalles Bibliográficos
Autores principales: Kurniawan, Fredy, Shi, Ke, Kurahashi, Kayo, Bielinsky, Anja-Katrin, Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994768/
https://www.ncbi.nlm.nih.gov/pubmed/29901028
http://dx.doi.org/10.1016/j.isci.2018.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994768/
https://www.ncbi.nlm.nih.gov/pubmed/29901028
http://dx.doi.org/10.1016/j.isci.2018.04.011

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