An MG53-IRS1-interaction disruptor ameliorates insulin resistance

Mitsugumin 53 (MG53) is an E3 ligase that induces insulin receptor substrate-1 (IRS-1) ubiquitination and degradation in skeletal muscle. We previously demonstrated that the pharmaceutical disruption of the MG53-IRS-1 interaction improves insulin sensitivity by abrogating IRS-1 ubiquitination and in...

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Detalles Bibliográficos
Autores principales: Park, Jun Sub, Lee, Hyun, Choi, Bo Woon, Ro, Seonggu, Lee, Doyoung, Na, Jeong Eun, Hong, Jeoung-Ho, Lee, Jae-Seon, Kim, Bong-Woo, Ko, Young-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994830/
https://www.ncbi.nlm.nih.gov/pubmed/29884820
http://dx.doi.org/10.1038/s12276-018-0099-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994830/
https://www.ncbi.nlm.nih.gov/pubmed/29884820
http://dx.doi.org/10.1038/s12276-018-0099-9

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