Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin

Fas associated phosphatase 1 (Fap1) is a ubiquitously expressed protein tyrosine phosphatase. Fap1 substrates include Fas and Gsk3β, suggesting a role in regulating cell survival. Consistent with this, increased Fap1 expression is associated with resistance to Fas or platinum induced apoptosis in so...

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Detalles Bibliográficos
Autores principales: Huang, Weiqi, Bei, Ling, Eklund, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995227/
https://www.ncbi.nlm.nih.gov/pubmed/29899829
http://dx.doi.org/10.18632/oncotarget.25401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995227/
https://www.ncbi.nlm.nih.gov/pubmed/29899829
http://dx.doi.org/10.18632/oncotarget.25401

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