Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer

Hepatocyte nuclear factors (HNF) are transcription factors that crucially regulate cell-specific gene expression in many tissues, including the liver. Of these factors, HNF4A acts both as a master regulator of liver organogenesis and a tumor suppressor in the liver. In our whole genome sequencing an...

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Detalles Bibliográficos
Autores principales: Taniguchi, Hiroaki, Fujimoto, Akihiro, Kono, Hidetoshi, Furuta, Mayuko, Fujita, Masashi, Nakagawa, Hidewaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995239/
https://www.ncbi.nlm.nih.gov/pubmed/29899848
http://dx.doi.org/10.18632/oncotarget.25456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995239/
https://www.ncbi.nlm.nih.gov/pubmed/29899848
http://dx.doi.org/10.18632/oncotarget.25456

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