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Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer

Hepatocyte nuclear factors (HNF) are transcription factors that crucially regulate cell-specific gene expression in many tissues, including the liver. Of these factors, HNF4A acts both as a master regulator of liver organogenesis and a tumor suppressor in the liver. In our whole genome sequencing an...

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Detalles Bibliográficos
Autores principales:	Taniguchi, Hiroaki, Fujimoto, Akihiro, Kono, Hidetoshi, Furuta, Mayuko, Fujita, Masashi, Nakagawa, Hidewaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995239/ https://www.ncbi.nlm.nih.gov/pubmed/29899848 http://dx.doi.org/10.18632/oncotarget.25456

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