Activated matriptase as a target to treat breast cancer with a drug conjugate

The antitumor effects of a novel antibody drug conjugate (ADC) was tested against human solid tumor cell lines and against human triple negative breast cancer (TNBC) xenografts in immunosuppressed mice. The ADC targeting activated matriptase of tumor cells was synthesized by using the potent anti-tu...

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Detalles Bibliográficos
Autores principales: Rather, Gulam M., Lin, Siang-Yo, Lin, Hongxia, Banach-Petrosky, Whitney, Hirshfield, Kim M., Lin, Chen-Yong, Johnson, Michael D., Szekely, Zoltan, Bertino, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995259/
https://www.ncbi.nlm.nih.gov/pubmed/29899836
http://dx.doi.org/10.18632/oncotarget.25414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995259/
https://www.ncbi.nlm.nih.gov/pubmed/29899836
http://dx.doi.org/10.18632/oncotarget.25414

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