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Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation

Chimeric mice have been generated by injecting pluripotent stem cells into morula-to-blastocyst stage mouse embryo or by introducing more mature cells into later stage embryos that correspond to the differentiation stage of the donor cells. It has not been rigorously tested, however, whether success...

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Detalles Bibliográficos
Autores principales: Cohen, Malkiel A., Markoulaki, Styliani, Jaenisch, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995271/
https://www.ncbi.nlm.nih.gov/pubmed/29606614
http://dx.doi.org/10.1016/j.stemcr.2018.03.004