Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling

INTRODUCTION: Minichromosome maintenance 10 (MCM10) is deregulated in several malignancies including cervical cancer and urothelial carcinoma. However, the expression and biologic role of MCM10 in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS: In this study, we performed immuno...

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Detalles Bibliográficos
Autores principales: Yan, Jie, Du, Pan, Jia, Yongxu, Chang, Zhiwei, Gan, Silin, Xu, Xiaohan, Wang, Yaohe, Qin, Yanru, Kan, Quancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995424/
https://www.ncbi.nlm.nih.gov/pubmed/29922071
http://dx.doi.org/10.2147/OTT.S157025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995424/
https://www.ncbi.nlm.nih.gov/pubmed/29922071
http://dx.doi.org/10.2147/OTT.S157025

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