Cargando…

Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling

INTRODUCTION: Minichromosome maintenance 10 (MCM10) is deregulated in several malignancies including cervical cancer and urothelial carcinoma. However, the expression and biologic role of MCM10 in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS: In this study, we performed immuno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Jie, Du, Pan, Jia, Yongxu, Chang, Zhiwei, Gan, Silin, Xu, Xiaohan, Wang, Yaohe, Qin, Yanru, Kan, Quancheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995424/ https://www.ncbi.nlm.nih.gov/pubmed/29922071 http://dx.doi.org/10.2147/OTT.S157025

Ejemplares similares

Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling [Retraction]
Publicado: (2018)

Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma
por: Hao, Jingcheng, et al.
Publicado: (2021)

CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses
por: Yuan, Ming, et al.
Publicado: (2016)

CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation
por: Zuo, Zhihong, et al.
Publicado: (2023)

Clinical efficacy and survival analysis of apatinib combined with docetaxel in advanced esophageal cancer
por: Li, Jing, et al.
Publicado: (2019)

Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9
por: Lv, Ji-Neng, et al.
Publicado: (2017)

CRISPR-Cas9 HDR system enhances AQP1 gene expression
por: Wang, Zhimin, et al.
Publicado: (2017)

Single‐Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma
por: Jia, Yongxu, et al.
Publicado: (2023)

Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
por: Zhu, Yuwei, et al.
Publicado: (2018)

CRISPR/Cas9 Knockout Strategies to Ablate CCAT1 lncRNA Gene in Cancer Cells
por: Zare, Khadijeh, et al.
Publicado: (2018)

CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
por: Chen, Chen, et al.
Publicado: (2023)

Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients
por: Tang, Hong, et al.
Publicado: (2017)

Circ-SFMBT2 drives the malignant phenotypes of esophageal cancer by the miR-107-dependent regulation of SLC1A5
por: Chang, Zhiwei, et al.
Publicado: (2021)

Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system
por: Miao, Jinxin, et al.
Publicado: (2022)

A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9
por: Yuan, Ming, et al.
Publicado: (2015)

MCM2-7 in Clear Cell Renal Cell Carcinoma: MCM7 Promotes Tumor Cell Proliferation
por: Zhang, Junneng, et al.
Publicado: (2021)

CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy
por: Guo, Xuan, et al.
Publicado: (2021)

Ablation of OCT4 function in cattle embryos by double electroporation of CRISPR-Cas for DNA and RNA targeting (CRISPR-DART)
por: Nix, Jada L, et al.
Publicado: (2023)

CRISPR/Cas9 in plant biotechnology: applications and challenges
por: Gan, Wen Cong, et al.
Publicado: (2022)

MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast
por: Akman, Gökhan, et al.
Publicado: (2009)

MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis()()
por: Issac, Marianne Samir Makboul, et al.
Publicado: (2019)

PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
por: Gleditzsch, Daniel, et al.
Publicado: (2018)

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene
por: Park, Ki-Eun, et al.
Publicado: (2017)

The Rise of CRISPR/Cas for Genome Editing in Stem Cells
por: Shui, Bing, et al.
Publicado: (2016)

Current advances of CRISPR-Cas technology in cell therapy
por: Qiu, Hou-Yuan, et al.
Publicado: (2022)

Single cell variability of CRISPR‐Cas interference and adaptation
por: McKenzie, Rebecca E, et al.
Publicado: (2022)

CRISPR/Cas9 Technique for Temperature, Drought, and Salinity Stress Responses
por: Li, Xiaohan, et al.
Publicado: (2022)

Efficient CRISPR/Cas9-Mediated BAX Gene Ablation in CHO Cells To Impair Apoptosis and Enhance Recombinant Protein Production
por: Rahimi, Amirabbas, et al.
Publicado: (2023)

Phosphorylation of Mcm2 modulates Mcm2–7 activity and affects the cell’s response to DNA damage
por: Stead, Brent E., et al.
Publicado: (2011)

Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools
por: Zhu, Yuwei, et al.
Publicado: (2019)

MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions(,)
por: Choy, Bonnie, et al.
Publicado: (2016)

Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway
por: Chen, Yuanyang, et al.
Publicado: (2021)

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing
por: Duan, Li, et al.
Publicado: (2021)

Molecular functions of MCM8 and MCM9 and their associated pathologies
por: Helderman, Noah Cornelis, et al.
Publicado: (2023)

Valproic Acid Inhibits Peripheral T Cell Lymphoma Cells Behaviors via Restraining PI3K/AKT Pathway
por: Peng, Zhiqiang, et al.
Publicado: (2022)

CRISPR/Cas9-based gene activation and base editing in Populus
por: Yao, Tao, et al.
Publicado: (2023)

Editorial: The CRISPR/Cas System in Pathogen Resistance, Virulence, Diagnosis and Typing
por: Duan, Guangcai, et al.
Publicado: (2022)

Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system
por: Sokolowski, Richard D., et al.
Publicado: (2014)

RACK1 promotes lung cancer cell growth via an MCM7/RACK1/Akt signaling complex
por: Fei, Liangru, et al.
Publicado: (2017)

CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching
por: Movahedi Motlagh, Fatemeh, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i0jn9hmkbr5utgunolh10u66ra