Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in diastole. This study aimed to develop a high throug...

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Detalles Bibliográficos
Autores principales: Liss, Martin, Radke, Michael H., Eckhard, Jamina, Neuenschwander, Martin, Dauksaite, Vita, von Kries, Jens-Peter, Gotthardt, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995442/
https://www.ncbi.nlm.nih.gov/pubmed/29889873
http://dx.doi.org/10.1371/journal.pone.0198492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995442/
https://www.ncbi.nlm.nih.gov/pubmed/29889873
http://dx.doi.org/10.1371/journal.pone.0198492

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