Autophagy regulates exosomal release of prions in neuronal cells

Prions are protein-based infectious agents that autocatalytically convert the cellular prion protein PrP(C) to its pathological isoform PrP(Sc). Subsequent aggregation and accumulation of PrP(Sc) in nervous tissues causes several invariably fatal neurodegenerative diseases in humans and animals. Pri...

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Detalles Bibliográficos
Autores principales: Abdulrahman, Basant A., Abdelaziz, Dalia H., Schatzl, Hermann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995502/
https://www.ncbi.nlm.nih.gov/pubmed/29700113
http://dx.doi.org/10.1074/jbc.RA117.000713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995502/
https://www.ncbi.nlm.nih.gov/pubmed/29700113
http://dx.doi.org/10.1074/jbc.RA117.000713

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