An actin cytoskeletal barrier inhibits lytic granule release from natural killer cells in patients with Chediak-Higashi syndrome

BACKGROUND: Chediak-Higashi syndrome (CHS) is a rare disorder caused by biallelic mutations in the lysosomal trafficking regulator gene (LYST), resulting in formation of giant lysosomes or lysosome-related organelles in several cell types. The disease is characterized by immunodeficiency and a fatal...

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Detalles Bibliográficos
Autores principales: Gil-Krzewska, Aleksandra, Saeed, Mezida B., Oszmiana, Anna, Fischer, Elizabeth R., Lagrue, Kathryn, Gahl, William A., Introne, Wendy J., Coligan, John E., Davis, Daniel M., Krzewski, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995607/
https://www.ncbi.nlm.nih.gov/pubmed/29241728
http://dx.doi.org/10.1016/j.jaci.2017.10.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995607/
https://www.ncbi.nlm.nih.gov/pubmed/29241728
http://dx.doi.org/10.1016/j.jaci.2017.10.040

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