PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain

ALG-2 interacting protein X (ALIX) links HIV-1 Gag to the components of ESCRT-III. HIV-1 engages the ALIX via its nucleocapsid and LYPXnL motif in p6. Overexpression of ALIX corrects the release defect of PTAP deleted HIV-1 via LYPXnL/ALIX pathway. However, HIV-1 subtype C lacks the LYPXnL motif and...

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Detalles Bibliográficos
Autores principales: Chaturbhuj, Devidas, Patil, Ajit, Gangakhedkar, Raman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995805/
https://www.ncbi.nlm.nih.gov/pubmed/29891975
http://dx.doi.org/10.1038/s41598-018-27162-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995805/
https://www.ncbi.nlm.nih.gov/pubmed/29891975
http://dx.doi.org/10.1038/s41598-018-27162-1

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