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PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain
ALG-2 interacting protein X (ALIX) links HIV-1 Gag to the components of ESCRT-III. HIV-1 engages the ALIX via its nucleocapsid and LYPXnL motif in p6. Overexpression of ALIX corrects the release defect of PTAP deleted HIV-1 via LYPXnL/ALIX pathway. However, HIV-1 subtype C lacks the LYPXnL motif and...
Autores principales: | Chaturbhuj, Devidas, Patil, Ajit, Gangakhedkar, Raman |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995805/ https://www.ncbi.nlm.nih.gov/pubmed/29891975 http://dx.doi.org/10.1038/s41598-018-27162-1 |
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