A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin

Botulinum neurotoxin (BoNT) is responsible for botulism, a clinical condition resulting in flaccid muscle paralysis and potentially death. The light chain is responsible for its intracellular toxicity through its endopeptidase activity. Available crystal structures of BoNT/A light chains (LCA) are b...

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Detalles Bibliográficos
Autores principales: Feltrup, Thomas M., Patel, Kruti, Kumar, Raj, Cai, Shuowei, Singh, Bal Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995822/
https://www.ncbi.nlm.nih.gov/pubmed/29891845
http://dx.doi.org/10.1038/s41598-018-26764-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995822/
https://www.ncbi.nlm.nih.gov/pubmed/29891845
http://dx.doi.org/10.1038/s41598-018-26764-z

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