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A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin
Botulinum neurotoxin (BoNT) is responsible for botulism, a clinical condition resulting in flaccid muscle paralysis and potentially death. The light chain is responsible for its intracellular toxicity through its endopeptidase activity. Available crystal structures of BoNT/A light chains (LCA) are b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995822/ https://www.ncbi.nlm.nih.gov/pubmed/29891845 http://dx.doi.org/10.1038/s41598-018-26764-z |