Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

High throughput screening (HTS) programs have demonstrated that the Vitamin D receptor (VDR) is activated and/or antagonized by a wide range of structurally diverse chemicals. In this study, we examined the Tox21 qHTS data set generated against VDR for reproducibility and concordance and elucidated...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahapatra, Debabrata, Franzosa, Jill A., Roell, Kyle, Kuenemann, Melaine Agnes, Houck, Keith A., Reif, David M., Fourches, Denis, Kullman, Seth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995905/
https://www.ncbi.nlm.nih.gov/pubmed/29891985
http://dx.doi.org/10.1038/s41598-018-27055-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995905/
https://www.ncbi.nlm.nih.gov/pubmed/29891985
http://dx.doi.org/10.1038/s41598-018-27055-3

Ejemplares similares