Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

High throughput screening (HTS) programs have demonstrated that the Vitamin D receptor (VDR) is activated and/or antagonized by a wide range of structurally diverse chemicals. In this study, we examined the Tox21 qHTS data set generated against VDR for reproducibility and concordance and elucidated...

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Detalles Bibliográficos
Autores principales: Mahapatra, Debabrata, Franzosa, Jill A., Roell, Kyle, Kuenemann, Melaine Agnes, Houck, Keith A., Reif, David M., Fourches, Denis, Kullman, Seth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995905/
https://www.ncbi.nlm.nih.gov/pubmed/29891985
http://dx.doi.org/10.1038/s41598-018-27055-3

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