Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′UTR lengths, production of which is influenced by cellular conditions. Here, we show that arsenic stress elicits global shortening of 3′UTRs through preferential usage of proximal polyadenylation sites during s...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Dinghai, Wang, Ruijia, Ding, Qingbao, Wang, Tianying, Xie, Bingning, Wei, Lu, Zhong, Zhaohua, Tian, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995920/
https://www.ncbi.nlm.nih.gov/pubmed/29891946
http://dx.doi.org/10.1038/s41467-018-04730-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995920/
https://www.ncbi.nlm.nih.gov/pubmed/29891946
http://dx.doi.org/10.1038/s41467-018-04730-7

Ejemplares similares