The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion

Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1Ea, proIGF-1Eb and proIGF-1Ec. These proIGF-1s have a common IGF-1 mature sequence but diff...

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Detalles Bibliográficos
Autores principales: Annibalini, Giosuè, Contarelli, Serena, De Santi, Mauro, Saltarelli, Roberta, Di Patria, Laura, Guescini, Michele, Villarini, Anna, Brandi, Giorgio, Stocchi, Vilberto, Barbieri, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995926/
https://www.ncbi.nlm.nih.gov/pubmed/29891966
http://dx.doi.org/10.1038/s41598-018-27233-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995926/
https://www.ncbi.nlm.nih.gov/pubmed/29891966
http://dx.doi.org/10.1038/s41598-018-27233-3

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