A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions

BACKGROUND: Monoclonal antibodies blocking the Cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor have revolutionized the field of anti-cancer therapy for the last few years. The human T-cell-based immune responses are modulated by two contradicting signals. CTLA-4 provides a T cell inhibitory signa...

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Detalles Bibliográficos
Autores principales: Ganesan, Aravindhan, Arulraj, Theinmozhi, Choulli, Tahir, Barakat, Khaled H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996525/
https://www.ncbi.nlm.nih.gov/pubmed/29890992
http://dx.doi.org/10.1186/s12911-018-0606-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996525/
https://www.ncbi.nlm.nih.gov/pubmed/29890992
http://dx.doi.org/10.1186/s12911-018-0606-x

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