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A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions

BACKGROUND: Monoclonal antibodies blocking the Cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor have revolutionized the field of anti-cancer therapy for the last few years. The human T-cell-based immune responses are modulated by two contradicting signals. CTLA-4 provides a T cell inhibitory signa...

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Detalles Bibliográficos
Autores principales:	Ganesan, Aravindhan, Arulraj, Theinmozhi, Choulli, Tahir, Barakat, Khaled H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996525/ https://www.ncbi.nlm.nih.gov/pubmed/29890992 http://dx.doi.org/10.1186/s12911-018-0606-x

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