Tetanus toxin fragments and Bcl-2 fusion proteins: cytoprotection and retrograde axonal migration

BACKGROUND: Tetanus neurotoxin (TeNT) is taken up at nerve terminals and undergoes retrograde migration. The toxic properties of TeNT reside in the toxin light chain (L), but like complete TeNT, the TeNT heavy chain (TTH) and the C-terminal domain (TTC) alone can bind and enter into neurons. Here, w...

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Detalles Bibliográficos
Autores principales: Watanabe, Yasuhiro, Matsuba, Takashi, Nakanishi, Mami, Une, Mio, Hanajima, Ritsuko, Nakashima, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996528/
https://www.ncbi.nlm.nih.gov/pubmed/29890980
http://dx.doi.org/10.1186/s12896-018-0452-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996528/
https://www.ncbi.nlm.nih.gov/pubmed/29890980
http://dx.doi.org/10.1186/s12896-018-0452-z

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