d-Alanyl-d-Alanine Ligase as a Broad-Host-Range Counterselection Marker in Vancomycin-Resistant Lactic Acid Bacteria

The peptidoglycan composition in lactic acid bacteria dictates vancomycin resistance. Vancomycin binds relatively poorly to peptidoglycan ending in d-alanyl-d-lactate and binds with high affinity to peptidoglycan ending in d-alanyl-d-alanine (d-Ala-d-Ala), which results in vancomycin resistance and...

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Detalles Bibliográficos
Autores principales: Zhang, Shenwei, Oh, Jee-Hwan, Alexander, Laura M., Özçam, Mustafa, van Pijkeren, Jan-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996685/
https://www.ncbi.nlm.nih.gov/pubmed/29686137
http://dx.doi.org/10.1128/JB.00607-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996685/
https://www.ncbi.nlm.nih.gov/pubmed/29686137
http://dx.doi.org/10.1128/JB.00607-17

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