Staphylococcus aureus Phenol-Soluble Modulins α1–α3 Act as Novel Toll-Like Receptor (TLR) 4 Antagonists to Inhibit HMGB1/TLR4/NF-κB Signaling Pathway

Phenol-soluble modulins (PSMs) have recently emerged as key virulence determinants, particularly in highly aggressive Staphylococcus aureus isolates. These peptides contribute to the pathogenesis of S. aureus infections, participating in multiple inflammatory responses. Here, we report a new role fo...

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Detalles Bibliográficos
Autores principales: Chu, Ming, Zhou, Mingya, Jiang, Caihong, Chen, Xi, Guo, Likai, Zhang, Mingbo, Chu, Zhengyun, Wang, Yuedan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996891/
https://www.ncbi.nlm.nih.gov/pubmed/29922279
http://dx.doi.org/10.3389/fimmu.2018.00862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996891/
https://www.ncbi.nlm.nih.gov/pubmed/29922279
http://dx.doi.org/10.3389/fimmu.2018.00862

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