Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris

Pemphigus vulgaris (PV) is a potentially lethal autoimmune disease characterized by blister formation of the skin and mucous membranes and is caused by autoantibodies against desmoglein (Dsg) 1 and Dsg3. Dsg1 and Dsg3 are linked to keratin filaments in desmosomes, adhering junctions abundant in tiss...

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Detalles Bibliográficos
Autores principales: Schlögl, Elisabeth, Radeva, Mariya Y., Vielmuth, Franziska, Schinner, Camilla, Waschke, Jens, Spindler, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996934/
https://www.ncbi.nlm.nih.gov/pubmed/29922278
http://dx.doi.org/10.3389/fimmu.2018.00858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996934/
https://www.ncbi.nlm.nih.gov/pubmed/29922278
http://dx.doi.org/10.3389/fimmu.2018.00858

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