A complex molecular switch directs stress-induced cyclin C nuclear release through SCF(Grr1)-mediated degradation of Med13

In response to oxidative stress, cells decide whether to mount a survival or cell death response. The conserved cyclin C and its kinase partner Cdk8 play a key role in this decision. Both are members of the Cdk8 kinase module, which, with Med12 and Med13, associate with the core mediator complex of...

Descripción completa

Detalles Bibliográficos
Autores principales: Stieg, David C., Willis, Stephen D., Ganesan, Vidyaramanan, Ong, Kai Li, Scuorzo, Joseph, Song, Mia, Grose, Julianne, Strich, Randy, Cooper, Katrina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996960/
https://www.ncbi.nlm.nih.gov/pubmed/29212878
http://dx.doi.org/10.1091/mbc.E17-08-0493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996960/
https://www.ncbi.nlm.nih.gov/pubmed/29212878
http://dx.doi.org/10.1091/mbc.E17-08-0493

Ejemplares similares