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A complex molecular switch directs stress-induced cyclin C nuclear release through SCF(Grr1)-mediated degradation of Med13

In response to oxidative stress, cells decide whether to mount a survival or cell death response. The conserved cyclin C and its kinase partner Cdk8 play a key role in this decision. Both are members of the Cdk8 kinase module, which, with Med12 and Med13, associate with the core mediator complex of...

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Detalles Bibliográficos
Autores principales:	Stieg, David C., Willis, Stephen D., Ganesan, Vidyaramanan, Ong, Kai Li, Scuorzo, Joseph, Song, Mia, Grose, Julianne, Strich, Randy, Cooper, Katrina F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996960/ https://www.ncbi.nlm.nih.gov/pubmed/29212878 http://dx.doi.org/10.1091/mbc.E17-08-0493

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