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External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein

A crucial mechanism to the formation of native, fully functional, 3D structures from local secondary structures is unraveled in this study. Through the introduction of various amino acid substitutions at four canonical β-turns in a three-fingered protein, Toxin α from Naja nigricollis, we found that...

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Detalles Bibliográficos
Autores principales: Sato, Atsushi, Menez, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997310/
https://www.ncbi.nlm.nih.gov/pubmed/29894484
http://dx.doi.org/10.1371/journal.pone.0198276