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External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein
A crucial mechanism to the formation of native, fully functional, 3D structures from local secondary structures is unraveled in this study. Through the introduction of various amino acid substitutions at four canonical β-turns in a three-fingered protein, Toxin α from Naja nigricollis, we found that...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997310/ https://www.ncbi.nlm.nih.gov/pubmed/29894484 http://dx.doi.org/10.1371/journal.pone.0198276 |