FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator...

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Detalles Bibliográficos
Autores principales: Dimitrova, Emilia, Kondo, Takashi, Feldmann, Angelika, Nakayama, Manabu, Koseki, Yoko, Konietzny, Rebecca, Kessler, Benedikt M, Koseki, Haruhiko, Klose, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997449/
https://www.ncbi.nlm.nih.gov/pubmed/29809150
http://dx.doi.org/10.7554/eLife.37084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997449/
https://www.ncbi.nlm.nih.gov/pubmed/29809150
http://dx.doi.org/10.7554/eLife.37084

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