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FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment
CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997449/ https://www.ncbi.nlm.nih.gov/pubmed/29809150 http://dx.doi.org/10.7554/eLife.37084 |