4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies

A series of novel 4-thiazolidinone inhibitors SKYa–SKYg, containing coumarin as a core structure were synthesized via facile and efficient method. The structures of the synthesized compounds were established by extensive spectroscopic studies (FT IR, 1D NMR, 2D NMR, LC–MS) and elemental analysis. Al...

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Detalles Bibliográficos
Autores principales: Yusufzai, Samina Khan, Osman, Hasnah, Khan, Mohammad Shaheen, Abd Razik, Basma M., Ezzat, Mohammed Oday, Mohamad, Suriyati, Sulaiman, Othman, Gansau, Jualang Azlan, Parumasivam, Thaigarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997609/
https://www.ncbi.nlm.nih.gov/pubmed/29896651
http://dx.doi.org/10.1186/s13065-018-0435-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997609/
https://www.ncbi.nlm.nih.gov/pubmed/29896651
http://dx.doi.org/10.1186/s13065-018-0435-0

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