α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monomers generates beta sheet-rich oligomers that localis...

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Detalles Bibliográficos
Autores principales: Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997668/
https://www.ncbi.nlm.nih.gov/pubmed/29895861
http://dx.doi.org/10.1038/s41467-018-04422-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997668/
https://www.ncbi.nlm.nih.gov/pubmed/29895861
http://dx.doi.org/10.1038/s41467-018-04422-2

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