Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pK(a)) abolished p...

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Detalles Bibliográficos
Autores principales: Spahn, Viola, Del Vecchio, Giovanna, Rodriguez-Gaztelumendi, Antonio, Temp, Julia, Labuz, Dominika, Kloner, Michael, Reidelbach, Marco, Machelska, Halina, Weber, Marcus, Stein, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997768/
https://www.ncbi.nlm.nih.gov/pubmed/29895890
http://dx.doi.org/10.1038/s41598-018-27313-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997768/
https://www.ncbi.nlm.nih.gov/pubmed/29895890
http://dx.doi.org/10.1038/s41598-018-27313-4

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