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Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist
Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pK(a)) abolished p...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997768/ https://www.ncbi.nlm.nih.gov/pubmed/29895890 http://dx.doi.org/10.1038/s41598-018-27313-4 |