Cargando…

Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools

The accumulation and deposition of α-synuclein aggregates in brain tissue is the main event in the pathogenesis of different neurodegenerative disorders grouped under the term of synucleinopathies. They include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. To date,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paciotti, Silvia, Bellomo, Giovanni, Gatticchi, Leonardo, Parnetti, Lucilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997809/ https://www.ncbi.nlm.nih.gov/pubmed/29928254 http://dx.doi.org/10.3389/fneur.2018.00415

Ejemplares similares

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
por: Bellomo, Giovanni, et al.
Publicado: (2023)

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)
por: Herva, Maria Eugenia, et al.
Publicado: (2014)

Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification
por: Jung, Byung Chul, et al.
Publicado: (2017)

Highly Efficient Protein Misfolding Cyclic Amplification
por: Gonzalez-Montalban, Nuria, et al.
Publicado: (2011)

Glycoform-independent prion conversion by highly efficient, cell-based, protein misfolding cyclic amplification
por: Moudjou, Mohammed, et al.
Publicado: (2016)

Synucleins: New Data on Misfolding, Aggregation and Role in Diseases
por: Surguchov, Andrei, et al.
Publicado: (2022)

α‐Synuclein real‐time quaking‐induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism
por: van Rumund, Anouke, et al.
Publicado: (2019)

Understanding Intra-Species and Inter-Species Prion Conversion and Zoonotic Potential Using Protein Misfolding Cyclic Amplification
por: Peden, Alexander H., et al.
Publicado: (2021)

Inter- and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification
por: Harpaz, Erez, et al.
Publicado: (2023)

Development of α-Synuclein Real-Time Quaking-Induced Conversion as a Diagnostic Method for α-Synucleinopathies
por: Nakagaki, Takehiro, et al.
Publicado: (2021)

In vitro amplification of H-type atypical bovine spongiform encephalopathy by protein misfolding cyclic amplification
por: O‘Connor, Matthew J., et al.
Publicado: (2017)

Highly Efficient Amplification of Chronic Wasting Disease Agent by Protein Misfolding Cyclic Amplification with Beads (PMCAb)
por: Johnson, Chad J., et al.
Publicado: (2012)

Ultra-efficient Amplification of Abnormal Prion Protein by Modified Protein Misfolding Cyclic Amplification with Electric Current
por: Park, Jeong-Ho, et al.
Publicado: (2017)

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
por: Pace, Michael C., et al.
Publicado: (2018)

Measurement of CSF core Alzheimer disease biomarkers for routine clinical diagnosis: do fresh vs frozen samples differ?
por: Bellomo, Giovanni, et al.
Publicado: (2020)

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification
por: Bougard, Daisy, et al.
Publicado: (2018)

Import and Export of Misfolded α-Synuclein
por: Rodriguez, Lilia, et al.
Publicado: (2018)

Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers
por: Barba, Lorenzo, et al.
Publicado: (2022)

Lysosomal Ceramide Metabolism Disorders: Implications in Parkinson’s Disease
por: Paciotti, Silvia, et al.
Publicado: (2020)

Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies
por: Rossi, Marcello, et al.
Publicado: (2021)

Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion
por: Kang, Hae-Eun, et al.
Publicado: (2017)

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein
por: Krasnoslobodtsev, Alexey V., et al.
Publicado: (2012)

The Role of Lipids in the Initiation of α-Synuclein Misfolding
por: Kiechle, Martin, et al.
Publicado: (2020)

Phosphatidylethanolamine Binding Protein 1 (PEBP1) in Alzheimer’s Disease: ELISA Development and Clinical Validation
por: Wojdała, Anna Lidia, et al.
Publicado: (2022)

Misfolding and Amyloid Aggregation of Apomyoglobin
por: Iannuzzi, Clara, et al.
Publicado: (2013)

Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification
por: Moudjou, Mohammed, et al.
Publicado: (2013)

De Novo Generation of a Unique Cervid Prion Strain Using Protein Misfolding Cyclic Amplification
por: Meyerett-Reid, Crystal, et al.
Publicado: (2017)

Correlation between Bioassay and Protein Misfolding Cyclic Amplification for Variant Creutzfeldt-Jakob Disease Decontamination Studies
por: Bélondrade, Maxime, et al.
Publicado: (2020)

Baseline concentration of misfolded α‐synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease
por: Ning, H., et al.
Publicado: (2018)

Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt–Jakob disease prions is strongly seed and substrate dependent
por: Bélondrade, Maxime, et al.
Publicado: (2021)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Prion Disease Blood Test Using Immunoprecipitation and Improved Quaking-Induced Conversion
por: Orrú, Christina D., et al.
Publicado: (2011)

Optimization of the Real-Time Quaking-Induced Conversion Assay for Prion Disease Diagnosis
por: Zerr, Inga, et al.
Publicado: (2020)

The Use of Real-Time Quaking-Induced Conversion for the Diagnosis of Human Prion Diseases
por: Poleggi, Anna, et al.
Publicado: (2022)

Real-Time Quaking- Induced Conversion Assays for Prion Diseases, Synucleinopathies, and Tauopathies
por: Vascellari, Sarah, et al.
Publicado: (2022)

Application of real-time quaking-induced conversion in Creutzfeldt–Jakob disease surveillance
por: Hermann, Peter, et al.
Publicado: (2023)

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid
por: Kakuda, Keita, et al.
Publicado: (2019)

To catch a quake
por: Cochran, Elizabeth S.
Publicado: (2018)

Strain Typing of Classical Scrapie by Transgenic Mouse Bioassay Using Protein Misfolding Cyclic Amplification to Replace Primary Passage
por: Beck, Katy E., et al.
Publicado: (2013)

Cerebrospinal Fluid Biomarkers and Prediction of Conversion in Patients with Mild Cognitive Impairment: 4-Year Follow-Up in a Routine Clinical Setting
por: Lanari, Alessia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_q06d3hfhfl0jul5260t3vqpb7u