Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy

The pathological cascade leading from primary storage to neural cell dysfunction and death in metachromatic leukodystrophy (MLD) has been poorly elucidated in human-derived neural cell systems. In the present study, we have modeled the progression of pathological events during the differentiation of...

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Detalles Bibliográficos
Autores principales: Frati, Giacomo, Luciani, Marco, Meneghini, Vasco, De Cicco, Silvia, Ståhlman, Marcus, Blomqvist, Maria, Grossi, Serena, Filocamo, Mirella, Morena, Francesco, Menegon, Andrea, Martino, Sabata, Gritti, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997994/
https://www.ncbi.nlm.nih.gov/pubmed/29899471
http://dx.doi.org/10.1038/s41419-018-0737-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997994/
https://www.ncbi.nlm.nih.gov/pubmed/29899471
http://dx.doi.org/10.1038/s41419-018-0737-0

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