Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters

Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria. In this combination, a short-acting, artesunate is partnered...

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Detalles Bibliográficos
Autores principales: Ndung'u, Loise, Langat, Benard, Magiri, Esther, Ng'ang'a, Joseph, Irungu, Beatrice, Nzila, Alexis, Kiboi, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998014/
https://www.ncbi.nlm.nih.gov/pubmed/29946569
http://dx.doi.org/10.12688/wellcomeopenres.11768.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998014/
https://www.ncbi.nlm.nih.gov/pubmed/29946569
http://dx.doi.org/10.12688/wellcomeopenres.11768.2

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