The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity

Prion diseases are fatal neurodegenerative conditions of humans and vertebrate species. The transmissible prion agent is a novel infectious particle composed principally of PrP (Sc), an abnormal isomer of the normal host protein PrP (C). The only reliable method to detect mammalian prion infectivity...

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Detalles Bibliográficos
Autores principales: Thackray, Alana M., Andréoletti, Olivier, Bujdoso, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998032/
https://www.ncbi.nlm.nih.gov/pubmed/29946445
http://dx.doi.org/10.12688/f1000research.14753.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998032/
https://www.ncbi.nlm.nih.gov/pubmed/29946445
http://dx.doi.org/10.12688/f1000research.14753.1

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