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The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity
Prion diseases are fatal neurodegenerative conditions of humans and vertebrate species. The transmissible prion agent is a novel infectious particle composed principally of PrP (Sc), an abnormal isomer of the normal host protein PrP (C). The only reliable method to detect mammalian prion infectivity...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000 Research Limited
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998032/ https://www.ncbi.nlm.nih.gov/pubmed/29946445 http://dx.doi.org/10.12688/f1000research.14753.1 |